Pharmacokinetics and Pharmacodynamics of Nandrolone Esters

We studied healthy men who underwent blood sampling for
plasma nandrolone, testosterone and inhibin measurements
before and for 32 days after a single i.m. injection of 100 mg of
nandrolone ester in arachis oil. Twenty-three men were randomized
into groups receiving nandrolone phenylpropionate
(group 1, n 5 7) or nandrolone decanoate (group 2, n 5 6)
injected into the gluteal muscle in 4 ml of arachis oil vehicle or
nandrolone decanoate in 1 ml of arachis oil vehicle injected into
either the gluteal (group 3, n 5 5) or deltoid (group 4, n 5 5)
muscles. Plasma nandrolone, testosterone and inhibin concentrations
were analyzed by a mixed-effects indirect response
model. Plasma nandrolone concentrations were influenced
(P , .001) by different esters and injection sites, with higher and
earlier peaks with the phenylpropionate ester, compared with
the decanoate ester. After nandrolone decanoate injection, the
highest bioavailability and peak nandrolone levels were observed
with the 1-ml gluteal injection. Plasma testosterone
concentrations were also influenced (P , .001) by the ester and
injection site, with the most rapid, but briefest, suppression
being due to the phenylpropionate ester, whereas the most
sustained suppression was achieved with the 1-ml gluteal injection.
Plasma inhibin concentrations were also significantly
influenced by injection volume and site, with the lowest nadir
occurring after the nandrolone decanoate 1-ml gluteal injection.
Thus, the bioavailability and physiological effects of a nandrolone
ester in an oil vehicle are greatest when the ester is
injected in a small (1 ml vs. 4 ml) volume and into the gluteal vs.
deltoid muscle. We conclude that the side-chain ester and the
injection site and volume influence the pharmacokinetics and
pharmacodynamics of nandrolone esters in an oil vehicle in

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